Genetic, geographic & cultural factors that cause sickle-cell anemia

It is important to note that even genetic diseases are caused by multiple social, environmental and biological factors. This is particularly true in the case of sickle-cell anemia, a genetically inherited blood disorder usually found in people with West African ancestry (PBS 2001).  The following paper will summarize the genetic, geographic and cultural factors that contribute to the incidence of sickle-cell anemia and why this disease is called a “balanced polymorphism”. Continue reading

Hardy-Weinberg Equilibrium Theory

The Hardy-Weinberg Equilibrium Theory is a simple mathematical model for the modern definition of evolution  that can be used to track the changes in allele frequencies within a population from one generation to the next. It is based on the idea of that no evolution– genetic equilibrium–is statistically unlikely. However, the hypothetical instance of no evolution can serve as a baseline in order to estimate and predict instances of allele frequency changes (evolutionary change) in descendent populations solely based on the proportion of phenotypic variances within a population (Jurmain 2010:438). Continue reading